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Target intelligence / Profile preview
FMS Proto-oncogene Tyrosine-Protein Kinase (CSF1R)
- Target
- CSF1R
- Molecular classification
- Tyrosine-protein kinase, Receptor, PDGF/CSF receptor family, Enzyme
01
Overview
FMS Proto-oncogene Tyrosine-Protein Kinase (CSF1R) is a receptor tyrosine kinase that plays a crucial role in regulating the survival, proliferation, and differentiation of myeloid lineage cells, particularly macrophages. It is activated by its ligands, CSF-1 and IL-34, leading to downstream signaling through PI3K/Akt, MAPK/ERK, JNK, and SRC pathways. CSF1R is implicated in various diseases, including ALSP leukoencephalopathy and myeloid malignancies, and is a therapeutic target for cancer, neurodegenerative diseases, and inflammatory bone diseases.
- Other names
- Colony Stimulating Factor 1 ReceptorMacrophage Colony-Stimulating Factor ReceptorM-CSFRCD115c-FMS
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell survivalCell proliferationCell differentiationMyeloid cell developmentMicroglial homeostasisNeurogenesisNeuronal survivalActin cytoskeleton organizationCell adhesionCell migrationCell invasion
04
Disease associations
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)Myeloid malignanciesLeukemiaCancerNeurodegenerative diseasesAlzheimer’s diseaseAmyotrophic Lateral Sclerosis (ALS)Inflammatory bone diseases
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