Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
fms-related tyrosine kinase 1 (FLT1)
- Target
- FLT1
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
FLT1, also known as VEGFR-1, is a receptor tyrosine kinase that plays a critical role in angiogenesis and vasculogenesis. It binds VEGF-A, VEGF-B, and PlGF. While it has lower intrinsic kinase activity compared to VEGFR2, it acts as a modulator of angiogenic signaling, serving as both a signaling receptor and a decoy to limit ligand availability for other receptors. Elevated levels of the soluble form, sFlt-1, are implicated in preeclampsia due to its antiangiogenic effects. Genetic variations in FLT1 are associated with cancer prognosis.
- Other names
- Vascular endothelial growth factor receptor 1VEGFR-1Flt-1sFlt-1 (soluble form)
02
Mechanism of action
Inhibition of VEGF/PlGF signaling through ligand sequestration or receptor blockade.
03
Biological functions
Angiogenesis regulationVasculogenesis regulationSignal transductionRegulation of endothelial cell migration
04
Disease associations
PreeclampsiaCancer
05
Safety considerations
Excessive anti-angiogenesis can lead to impaired wound healing and other vascular complications.
06
Biomarkers
sFlt-1 (Preeclampsia)FLT1 genetic variations (Cancer prognosis)
Beyond the preview
Go deeper on fms-related tyrosine kinase 1 (FLT1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on fms-related tyrosine kinase 1 (FLT1).