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Target intelligence / Profile preview
Fms-related tyrosine kinase 3 ligand (FLT3LG)
- Target
- FLT3LG
- Molecular classification
- Cytokine, Endogenous peptide
01
Overview
Fms-related tyrosine kinase 3 ligand (FLT3LG) is a cytokine protein that acts as a growth factor, playing a crucial role in hematopoiesis, particularly in the proliferation and differentiation of blood cell progenitors. It stimulates the development, expansion, and mobilization of dendritic cells and increases immune cell numbers. FLT3LG exerts its effects by binding to its receptor, FMS-like tyrosine kinase 3 (FLT3/CD135), which leads to receptor activation and downstream signaling.
- Other names
- FLT3LFlt-ligand
02
Mechanism of action
Binds and activates FMS-like tyrosine kinase 3 (FLT3/CD135) receptor, leading to receptor dimerization and autophosphorylation, triggering downstream signaling pathways.
03
Biological functions
HematopoiesisProliferation of blood cell progenitorsDifferentiation of blood cell progenitorsDendritic cell developmentDendritic cell expansionDendritic cell mobilizationImmune cell activation
04
Disease associations
CancerImmune system modulation
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