Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Fms-related tyrosine kinase 3 receptor (FLT3)
- Target
- FLT3
- Molecular classification
- Receptor Tyrosine Kinase, Class III Receptor Tyrosine Kinase
01
Overview
Fms-related tyrosine kinase 3 receptor (FLT3) is a class III receptor tyrosine kinase that plays a critical role in hematopoiesis. It is expressed almost exclusively in hematopoietic tissues, particularly on early hematopoietic progenitor cells. Activation by its ligand, FLT3LG, promotes survival, proliferation, and differentiation of these cells. Activating mutations in FLT3 are frequently found in acute myeloid leukemia (AML) and are associated with poor prognosis. Several small-molecule inhibitors targeting mutant or overactive FLT3 have been developed for cancer therapy, but resistance mechanisms can limit their long-term efficacy.
- Other names
- FLK2STK1
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Hematopoiesis regulationCell survivalCell proliferationCell differentiationSignal transduction
04
Disease associations
Acute Myeloid LeukemiaAutoimmune Diseases
05
Safety considerations
Resistance mechanismsOff-target effects
06
Interacting drugs
Sorafenib
07
Biomarkers
FLT3 mutations in AML
Beyond the preview
Go deeper on Fms-related tyrosine kinase 3 receptor (FLT3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Fms-related tyrosine kinase 3 receptor (FLT3).