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Target intelligence / Profile preview
Focal adhesion kinase-like 2 (FAK2)
- Target
- FAK2
- Molecular classification
- Enzyme, Protein tyrosine kinase, Non-receptor tyrosine kinase
01
Overview
Focal adhesion kinase-like 2 (FAK2), also known as Proline-rich tyrosine kinase 2 (Pyk2), is a cytoplasmic non-receptor protein tyrosine kinase closely related to canonical focal adhesion kinase (FAK). It regulates key cellular processes such as proliferation, survival signaling pathways downstream of integrins/growth factors—especially relevant for cell motility—and participates actively at sites where cells interact with their environment via the extracellular matrix. While not essential during embryonic development like its paralogous counterpart (FAK), it remains an important modulator within adult tissue homeostasis and disease states such as cancer progression due to its influence on invasive behavior.
- Other names
- Proline-rich tyrosine kinase 2Pyk2PTK2B
02
Mechanism of action
Inhibition of kinase activity; protein degradation
03
Biological functions
Cell proliferationCell survivalCell motilitySignal transductionRegulation of cell adhesionAssembly of signaling complexes
04
Disease associations
CancerTumorigenesisMetastasis
05
Safety considerations
Potential for off-target effects due to kinase family similarityDevelopment of resistance to inhibitors
06
Interacting drugs
Small-molecule inhibitors targeting FAK and Pyk2
1 more in the full profile.
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