Folate-Dependent Enzymes Involved in Nucleotide Synthesis (Folate-Dependent Nucleotide Enzymes)

Folate-dependent enzymes are a group of enzymes that utilize folate derivatives as cofactors to catalyze key reactions in the synthesis of nucleotides, which are essential for DNA and RNA production. These enzymes play critical roles in both purine and pyrimidine nucleotide biosynthesis pathways, supporting cell proliferation, DNA repair, and genomic stability. Key enzymes include Glycinamide Ribonucleotide Formyltransferase (GARFT), Aminoimidazole Carboxamide Ribonucleotide Formyltransferase (AICARFT), Thymidylate Synthase (TYMS), Dihydrofolate Reductase (DHFR), and Serine Hydroxymethyltransferase (SHMT). These enzymes are important therapeutic targets, and antifolate drugs are used in cancer therapy.

Other names

Folate-utilizing enzymes in nucleotide metabolismVitamin B9-dependent enzymesPurine and pyrimidine synthesis enzymesGARFTAICARFTTYMSDHFRSHMT

Enzyme inhibition