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Target intelligence / Profile preview
Folate Receptor (FR)
- Target
- FR
- Molecular classification
- Receptor, Glycoprotein
01
Overview
The folate receptor is a family of cell-surface glycoproteins that bind folate and reduced folic acid derivatives with high affinity, mediating their delivery into cells. Overexpression of folate receptors, particularly FRα, is observed in many cancers, making them attractive targets for diagnostic imaging and targeted therapies. The receptor facilitates folate uptake via endocytosis, a process crucial for DNA synthesis, cell proliferation, and DNA repair.
- Other names
- FOLR1FOLR2FOLR3FRαFRβFRγ
02
Mechanism of action
Mediates cellular uptake of folate via endocytosis, facilitating DNA synthesis and cell proliferation.
03
Biological functions
Folate transportEndocytosisDNA synthesisCell proliferationDNA repair
04
Disease associations
CancerEmbryogenesis
05
Safety considerations
Potential for off-target effects due to expression in normal tissues (e.g., kidney, placenta)Immune response to anti-FR antibodies
06
Interacting drugs
Anti-FRα antibodies
2 more in the full profile.
07
Biomarkers
FRα expression levels in tumors
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