Folate receptor 3 pseudogene 1 (FOLR3P1)

FOLR3P1 (Folate receptor 3 pseudogene 1) is a non-functional genomic segment located on chromosome 11 and classified as a pseudogene[1][7][5]. Pseudogenes like FOLR3P1 do not encode functional proteins due to accumulated disabling mutations or absence of regulatory elements required for expression[5]. While functional folate receptors (such as FOLR3, FOLR2, FOLR1) are involved in cellular folate uptake and metabolism[3][4][6][10], FOLR3P1 does not perform these functions and is considered biologically inactive[1][7]. As a result, it is not a therapeutic target, has no known biological role, disease association, or drug interactions. Key clarifications: - The gene is a pseudogene and does not code for a functional protein[1][5][7]. - Pseudogenes are not considered legitimate drug targets due to lack of functional expression[5]. - The *functional* folate receptors, such as Folate receptor gamma (FOLR3), do have biological roles, but FOLR3P1 does not[3][4][6]. - GeneCards and biogps both annotate this gene explicitly as a pseudogene, and provide no evidence for functional protein or therapeutic relevance for FOLR3P1[1][7]. If you are seeking information about the functional Folate receptor gamma (FOLR3), refer to FOLR3 (not FOLR3P1/ENSG00000255860)[3][4][6].

Other names

Folate receptor 3 (gamma) pseudogene 1ENSG00000255860