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Target intelligence / Profile preview
Folate Receptor Alpha (FRα)
- Target
- FRα
- Molecular classification
- Receptor, GPI-anchored protein
01
Overview
Folate receptor alpha (FRα) is a cell surface, glycosylphosphatidylinositol (GPI)-anchored glycoprotein that binds folate and reduced folic acid derivatives with high affinity. It mediates the delivery of 5-methyltetrahydrofolate and other folate analogs into cells, playing a crucial role in cellular uptake of folates. Due to its overexpression in many cancers and limited expression in normal tissues, it is a promising target for cancer therapy and diagnostics.
- Other names
- FOLR1Folate Binding Protein (FBP)
02
Mechanism of action
Various mechanisms depending on the targeting approach, including antibody-mediated cytotoxicity, drug delivery to cancer cells, and disruption of folate uptake.
03
Biological functions
Folate transportCellular uptake of folatesDNA synthesisMethylation reactions
04
Disease associations
Cancer
05
Safety considerations
Off-target effects in normal tissues expressing FRαDevelopment of resistanceImmunogenicity of antibodies
06
Interacting drugs
Folate-drug conjugates
2 more in the full profile.
07
Biomarkers
FRα expression levels in tumor tissueSoluble FRα in serum
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