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Target intelligence / Profile preview
Folate Receptor Beta (FRβ)
- Target
- FRβ
- Molecular classification
- Receptor, Folate Receptor Family
01
Overview
Folate receptor beta (FRβ) is a high-affinity folate-binding protein encoded by the FOLR2 gene. It mediates the transport of folates into cells through endocytosis. FRβ is upregulated on immunosuppressive tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), making it a promising target for cancer immunotherapy.
- Other names
- FOLR2Folate receptor 2
02
Mechanism of action
Drugs targeting FRβ can selectively reprogram TAMs/MDSCs from tumor-promoting M2-like phenotypes toward pro-inflammatory M1-like states. Antifolates exploit this pathway for selective drug delivery.
03
Biological functions
Folate transportEndocytosisImmune modulation
04
Disease associations
CancerInflammation
05
Safety considerations
Potential for off-target effects if drugs targeting FRβ also affect normal tissue macrophages expressing low levels of the receptor.Risk of immune-related adverse events due to modulation of the tumor microenvironment.Possibility of drug resistance development
06
Interacting drugs
Folic acid
3 more in the full profile.
07
Biomarkers
FRβ expression level in tumor-associated macrophages (TAMs)FRβ expression level in myeloid-derived suppressor cells (MDSCs)
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