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Target intelligence / Profile preview
Folate Receptor Gamma (FOLR3)
- Target
- FOLR3
- Molecular classification
- Receptor, Secreted protein
01
Overview
Folate receptor gamma (FOLR3) is a secreted protein involved in folate uptake and homocysteine regulation. It is primarily expressed in hematopoietic tissues and has been implicated in fibrogenesis and metabolic dysfunction-associated steatohepatitis (MASH), suggesting its potential as a therapeutic target for liver fibrosis.
- Other names
- FR-GFR-gammagamma-hFRfolate receptor 3 (gamma)FRgamma
02
Mechanism of action
Binds and transports folates, modulating one-carbon metabolism and homocysteine levels; implicated in TGFβ signaling amplification in liver fibrosis.
03
Biological functions
Folic acid bindingFolic acid transportHomocysteine regulation
04
Disease associations
FibrogenesisMetabolic dysfunction-associated steatohepatitis (MASH)
05
Interacting drugs
Folic acid
1 more in the full profile.
06
Biomarkers
FOLR3 expression levels in liver tissue for MASH/NASH diagnosis and stagingPlasma homocysteine levels
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