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Folic Acid Metabolic Pathway
- Molecular classification
- Metabolic Pathway
01
Overview
The folic acid (folate) metabolic pathway in bacteria is a biosynthetic route essential for the production of tetrahydrofolate (THF), a cofactor required for one-carbon transfer reactions involved in DNA, RNA, and amino acid synthesis. Unlike mammals, which must obtain folate from their diet, many bacteria can synthesize folic acid de novo from simple precursors. This pathway is critical for bacterial growth and survival and has been validated as an effective target for antibacterial drugs.
- Other names
- Folate Biosynthesis PathwayTetrahydrofolate Synthesis PathwayVitamin B9 Synthesis Pathway
02
Mechanism of action
Inhibition of bacterial folate synthesis enzymes (DHPS, DHFR)
03
Biological functions
Tetrahydrofolate (THF) synthesisOne-carbon transfer reactionsPurine synthesisThymidylate synthesisAmino acid synthesisDNA synthesisRNA synthesis
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistanceOff-target effects on host folate metabolism (though less likely due to differences in DHFR structure)Impact on gut microbial community composition
06
Interacting drugs
Sulfamethoxazole
1 more in the full profile.
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