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Folic acid metabolism
- Molecular classification
- Other (Metabolic pathway)
01
Overview
Folic acid metabolism refers to the biochemical pathways involving folate (vitamin B9) in the body. It is crucial for DNA synthesis, repair, and methylation, as well as amino acid metabolism. Folate coenzymes mediate the transfer of one-carbon units in these processes. The metabolism involves conversion of dietary folate into its active forms, such as tetrahydrofolate (THF) and 5-methyl-THF, which are essential for various cellular functions. Disruptions in folate metabolism can lead to conditions like megaloblastic anemia and increased risk of certain diseases. Drugs interacting with this pathway are used in cancer treatment and management of folate deficiency.
- Other names
- Folate metabolismVitamin B9 metabolism
02
Mechanism of action
Inhibition of dihydrofolate reductase (e.g., by methotrexate); Rescue of normal cells with folinic acid during methotrexate treatment
03
Biological functions
DNA synthesisRNA synthesisAmino acid metabolismMethylation of DNA and proteinsCell division
04
Disease associations
CancerCardiovascular diseaseNeurodegenerative diseaseBirth defects (e.g., neural tube defects)
05
Safety considerations
Toxicity of antifolate drugs (e.g., methotrexate)Potential for masking vitamin B12 deficiency with high doses of folic acid
06
Interacting drugs
Methotrexate
1 more in the full profile.
07
Biomarkers
Homocysteine levelsFolate serum levels
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