Follicular keratin and corneocyte cohesion structures

Follicular keratin and corneocyte cohesion structures refer to the complex of structural proteins and intercellular junctions that maintain the integrity of the hair follicle lining and the stratum corneum [1, 2]. This target primarily involves keratins (e.g., KRT1, KRT10) and corneodesmosomes, which are specialized desmosomes containing proteins like corneodesmosin (CDSN) and desmogleins [2]. In healthy skin, these structures undergo regulated degradation to allow for normal desquamation; however, in diseases like acne vulgaris, increased cohesion leads to follicular hyperkeratosis [1, 3]. This pathological process results in the formation of microcomedones, which are the precursor lesions for all acne types [3]. Pharmacological agents such as topical retinoids (e.g., tretinoin, adapalene) target these structures by binding to nuclear retinoic acid receptors, which subsequently downregulates the expression of genes involved in cell adhesion [4]. This action reduces the stickiness of corneocytes, facilitating their shedding and preventing the obstruction of the pilosebaceous duct [4]. Keratolytic agents like salicylic acid also interact with this target by chemically dissolving the intercellular cement, thereby promoting the breakdown of the keratinized plug [3]. Understanding the dynamics of these cohesion structures is critical for developing treatments that restore normal follicular flow and barrier function. [1] Williams HC, et al. Lancet. 2012;379(9813):361-72. [2] Caubet C, et al. J Invest Dermatol. 2004;122(5):1235-44. [3] Zaenglein AL, et al. J Am Acad Dermatol. 2016;74(5):945-73. [4] Leyden J, et al. Dermatol Ther (Heidelb). 2017;7(3):293-304.

Other names

CorneodesmosomesFollicular hyperkeratosis complexKeratinized follicular plugCorneocyte adhesive structuresPilosebaceous unit structural complex

Reduction of corneocyte adhesiveness through RAR-mediated gene modulation or chemical lysis of intercellular bridges to promote follicular desquamation.