Food-specific immunoglobulin G antibody (Food-specific IgG)

Food-specific immunoglobulin G antibody response refers to the production of IgG antibodies by the immune system in response to dietary antigens encountered in the gut. The presence of these antibodies in serum indicates exposure to specific foods and is generally considered part of the normal immune response, with higher levels sometimes associated with increased tolerance rather than intolerance. Blood tests claiming to diagnose food sensitivities based on food-specific IgG are widely criticized and not supported by guidelines from major allergy and immunology societies. These tests lack specificity and clinical validity, and results do not reliably predict symptoms or disease. The response should not be considered a therapeutic target, nor a diagnostic marker for food allergy or intolerance. Summary of expert consensus: Food-specific IgG is a normal immunologic phenomenon and not a validated biomarker for food intolerance, food allergy, or other disease diagnosis. Not a therapeutic target in any pharmacological or clinical context. Commercial tests based on food-specific IgG lack supporting research and may present risks due to unnecessary dietary restriction.

Other names

Food IgGFood-specific IgG antibodiesIgG-mediated food sensitivity/responseFS-IgG

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