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Target intelligence / Profile preview
Forkhead box C1 promoter upstream transcript (FOXCUT)
- Target
- FOXCUT
- Molecular classification
- Long non-coding RNA (lncRNA), Promoter upstream transcript (PROMPT), Non-protein-coding RNA
01
Overview
FOXCUT is a long non-coding RNA located upstream of the FOXC1 gene at chromosome 6p25, often designated as TCONS_00011636 or LINC01379[1][2][4][5]. It is functionally linked to the adjacent FOXC1 transcription factor, with elevated levels of FOXCUT expression correlated to increased expression of FOXC1 protein-coding transcript, cellular proliferation, migration, and overall tumor aggressiveness in multiple cancer types[1][2]. Experimental knockdown of FOXCUT by siRNA inhibits FOXC1 expression and consequently suppresses proliferation and migration of cancer cells. These characteristics highlight FOXCUT as a potential therapeutic target and diagnostic/prognostic biomarker in oncology, particularly basal-like breast cancer and esophageal squamous cell carcinoma[1][2].
- Other names
- FOXC1 upstream transcriptTCONS_00011636LINC01379FOXC1 promoter upstream transcriptlong intergenic non-protein coding RNA 1379
02
Biological functions
Regulation of cell proliferationRegulation of cell migrationModulation of gene expression (especially FOXC1)Facilitation of tumor aggressiveness and progression
03
Disease associations
Cancer (notably basal-like breast cancer, esophageal squamous cell carcinoma, and correlates with poor prognosis in other tumors such as pancreatic, lung, and liver cancer)May serve as a prognostic biomarker (poor differentiation, lymph node metastasis, high grade)
04
Biomarkers
FOXCUT expression (prognostic biomarker for aggressive and metastatic cancer subtypes, especially BLBC and ESCC)FOXC1 expression (strongly correlated with FOXCUT, together forming a lncRNA-mRNA biomarker pair)
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