Forkhead box O3B (pseudogene) (FOXO3B)

FOXO3B, also listed as Forkhead box O3B and several alternative names, is designated in reference databases as a **pseudogene** in the human genome, not as a protein-coding gene or a direct therapeutic target[7]. The functional, protein-coding paralog in humans is **Forkhead box O3 (FOXO3)**, which is a well-studied member of the FOXO family of transcription factors with major roles in cellular homeostasis, apoptosis, and tumor suppression[4]. In contrast, FOXO3B lacks evidence of encoding a functional protein and does not appear to participate in transcriptional regulation, disease mechanisms, or drug targeting. There is no current evidence that FOXO3B is clinically or therapeutically relevant as a molecular target, and its inclusion as a target is likely incorrect for drug discovery or biomarker applications[7]. **Key context:** - FOXO3B is a pseudogene, not a functional gene or therapeutic target[7]. - The canonical, functional target is **Forkhead box O3 (FOXO3, abbreviated FOXO3)**, not FOXO3B[4]. - No biological, pharmacological, or clinical associations reported for FOXO3B. **Summary:** FOXO3B should not be considered a therapeutic target, and if FOXO3/FOXO3a activity or targeting is intended, the correct canonical name is **Forkhead box O3 (FOXO3)**.

Other names

Forkhead box protein O3BFKHRL1P1ZNF286CForkhead box O3B pseudogeneforkhead(Drosophila) homolog (rhabdomyosarcoma) 1 like pseudogene 1Forkhead box O3B (pseudogene)