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Forkhead box P3 (FoxP3)
- Target
- FoxP3
- Molecular classification
- Transcription factor
01
Overview
FoxP3 is a transcription factor that is critical for the development, stability, and function of regulatory T cells (Tregs). Tregs play a central role in maintaining immune homeostasis, self-tolerance, and preventing autoimmune responses. FoxP3 acts as a lineage specification factor for Tregs, governing their genetic program and mediating their suppressive function. Deficiency or dysfunction in FoxP3 leads to severe systemic autoimmunity. Therapeutic manipulation aims at either enhancing FoxP3/Treg function (to treat autoimmunity) or inhibiting it (to boost anti-cancer immunity).
- Other names
- FOXP3scurfinIPEX
02
Mechanism of action
Enhancing or inhibiting FoxP3/Treg function
03
Biological functions
Immune suppressionMaintenance of toleranceLineage specification of regulatory T cellsRegulation of gene expression
04
Disease associations
Autoimmune diseaseCancerTransplant rejectionInflammation
05
Safety considerations
Treg plasticity and potential conversion to pro-inflammatory cellsPotential for immunosuppression leading to increased risk of infection or cancer
06
Biomarkers
FoxP3 expression level in Tregs
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