Forkhead box protein 3 (FOXP3)

FOXP3 (Forkhead box protein 3) is a transcription factor that serves as the master regulator of regulatory T cell (Treg) development and function. The stabilization of FOXP3 expression is critical for maintaining the identity, suppressive function, and lineage stability of Tregs, which are essential for immune tolerance and prevention of autoimmunity. Stabilization involves post-translational modifications (notably via USP7), epigenetic control at key genomic regions like the Foxp3-specific demethylated region, supportive cytokines like IL-2, specific transcription factors including C/EBPβ/CREB binding activities—and requires intact genetic structure including exon 2—for robust maintenance of immunoregulatory functions.

Other names

FOXP3JM2IPEXPIDXXPIDscurfin

Modulation of FOXP3 expression and stability