Forkhead box protein C2 antisense RNA 1 (FOXC2-AS1)

FOXC2-AS1, properly named **Forkhead box protein C2 antisense RNA 1 (FOXC2-AS1)**, is a long noncoding antisense RNA transcribed from the opposite strand of the FOXC2 gene. It is primarily localized to the nucleus and acts by forming a duplex with FOXC2 mRNA, stabilizing it and thereby upregulating FOXC2 expression. Elevated FOXC2-AS1 levels have been observed in multiple cancers, including colorectal, breast, prostate, and lung cancers, where its expression correlates with tumor proliferation, migration, metastasis, chemoresistance, and poor prognosis. Experimental knockdown of FOXC2-AS1 impairs cancer cell growth and metastasis, indicating its oncogenic function and its emerging status as a potential therapeutic target and prognostic biomarker[1][3][4]. **Important clarification:** There is no established gene or transcript known as "C2 antisense RNA 1" or "C2-AS1" in curated scientific databases; published literature and functional data refer to FOXC2-AS1 or Forkhead box C2 antisense RNA 1[1][4]. If your target is "C2-AS1," it is likely a misreading or truncated form of "FOXC2-AS1." Therefore, **the "C2 antisense RNA 1" or "C2-AS1" designation is incorrect and should be updated to FOXC2-AS1**.

Other names

FOXC2-AS1Forkhead box C2 antisense RNA 1FOXC2 antisense RNA 1

Enhances FOXC2 mRNA stability, promoting FOXC2 gene expression via RNA duplex formation. Influences intracellular calcium signaling (Ca2+-FAK pathway), promoting tumorigenesis and metastasis.