Forkhead box protein F1 (FOXF1)

Forkhead box protein F1 (FOXF1) is a transcription factor from the forkhead box (FOX) superfamily, distinguished by a conserved forkhead DNA-binding domain. FOXF1 plays a pivotal role in embryonic development, especially in the mesenchymal cells of the lung and gastrointestinal system, where it is essential for organ morphogenesis, cell migration, and maintenance of the endothelial barrier. In adults, FOXF1 contributes to tissue repair, regulates the endothelial barrier via the S1P/S1PR1 pathway, and participates in DNA repair and cell cycle control as an interacting partner of Fanconi anemia (FA) complex proteins. Mutations or deletions in FOXF1 cause severe developmental disorders such as ACDMPV, and altered FOXF1 function is implicated in certain cancers and possibly cardiac diseases due to its roles in cell migration, tissue remodeling, and protein quality control. There are currently no approved drugs that directly target FOXF1, and therapeutic modulation poses substantial safety concerns due to its crucial function in development and tissue integrity.

Other names

Forkhead box F1FKHL5FREAC1FREAC-1Forkhead-related activator 1Forkhead-related protein FKHL5Forkhead-related transcription factor 1ACDMPVHFH-8

Not applicable for direct drug targeting as no approved drugs directly target FOXF1; S1P acts via the S1P/S1PR1 pathway whose activity is modulated downstream by FOXF1