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Target intelligence / Profile preview
Forkhead box protein M1 (FOXM1)
- Target
- FOXM1
- Molecular classification
- Transcription factor, Forkhead box (FOX) family
01
Overview
Forkhead box protein M1 (FOXM1) is a transcription factor encoded by the FOXM1 gene in humans. It belongs to the forkhead box (FOX) family of transcription factors and plays a central role in regulating cell proliferation, cell cycle progression, DNA damage repair, and tissue homeostasis. Its abnormal upregulation is implicated in many human cancers and diabetes complications, making it an attractive target for therapeutic intervention.
- Other names
- Forkhead box transcription factor M1
02
Mechanism of action
Transcription factor that regulates the expression of target genes involved in cell proliferation, cell cycle progression, DNA damage repair, and tissue homeostasis.
03
Biological functions
Cell proliferationCell cycleDNA replicationDNA repairTissue homeostasisTissue regenerationStem cell pluripotencySelf-renewal
04
Disease associations
CancerDiabetes complicationsLiver cancerBreast cancerLung cancerProstate cancerColon cancerBrain cancersNephropathyRetinopathyCardiomyopathy
05
Safety considerations
Abnormal upregulation is implicated in many human cancersOverexpression leads to increased proliferation signalsSuppresses anti-proliferative responses
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