Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Forkhead box protein N2 (FOXN2)
- Target
- FOXN2
- Molecular classification
- Transcription factor, Forkhead box (FOX) family
01
Overview
Forkhead box protein N2 (FOXN2) is a member of the forkhead box (FOX) family of transcription factors characterized by a winged-helix DNA-binding domain[1][8]. It acts as a transcriptional regulator, including modulating the response elements in the long terminal repeat (LTR) of human T-cell leukemia virus (HTLV)[2][3]. FOXN2 functions as a tumor suppressor, regulating cell proliferation, migration, invasion, and therapeutic response in various cancer types; reduced expression or degradation of FOXN2 is linked with enhanced cancer aggressiveness and poorer patient outcomes. It is also implicated in transcriptional regulation of genes involved with immune and tissue-specific developmental processes[1][2][8].
- Other names
- Forkhead box N2HTLFHuman T-cell leukemia virus enhancer factorFOXN2
02
Biological functions
Transcriptional regulationDNA binding (sequence-specific)Regulation of cell proliferationRegulation of cell migration and invasionTumor suppression
03
Disease associations
Cancer (including lung, hepatocellular, cervical, and glioblastoma)Leukemia
04
Biomarkers
Prognostic marker in glioblastoma multiforme (low FOXN2 mRNA levels associated with poor survival)
Beyond the preview
Go deeper on Forkhead box protein N2 (FOXN2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Forkhead box protein N2 (FOXN2).