Formimidoyltransferase-cyclodeaminase (FTCD)

Formimidoyltransferase-cyclodeaminase (FTCD) is a bifunctional enzyme highly expressed in the liver, where it catalyzes the last two steps of histidine catabolism, coupling the degradation of histidine to folate metabolism by transferring a formimino group from formiminoglutamate (FIGLU) to tetrahydrofolate (THF), and then cyclodeaminating the resulting product to yield 5,10-methenyltetrahydrofolate and ammonia. FTCD is also structurally involved with the Golgi complex and the vimentin intermediate filament cytoskeleton, serving additional non-enzymatic cellular roles. Mutations in FTCD cause glutamate formiminotransferase deficiency, with presentation ranging from asymptomatic to metabolic disorder with high urinary FIGLU. FTCD is the target of specific autoantibodies in type 2 autoimmune hepatitis and has also been implicated as a tumor suppressor gene in hepatocellular carcinoma.

Other names

Formiminotransferase-cyclodeaminaseGlutamate formimidoyltransferaseFormimidoyltetrahydrofolate cyclodeaminaseFTCDLCHC1Glutamate formiminotransferaseGlutamate formyltransferaseFormiminotetrahydrofolate cyclodeaminaseformiminotransferase cyclodeaminaseformimidoyltransferase cyclodeaminase