Formin-binding protein 1-like (FNBP1L)

Formin-binding protein 1-like (FNBP1L) is an adaptor protein that contains an F-BAR domain and functions to connect membrane curvature with the assembly of the actin cytoskeleton and membrane trafficking. It binds to CDC42 and N-WASP, promoting CDC42-induced actin polymerization by activating the N-WASP-WIP complex, and links cell surface signals to actin cytoskeleton changes. FNBP1L is essential for xenophagic autophagy—specifically, it helps clear intracellular bacteria by organizing autophagy machinery at sites of pathogen entry, restricting microbial proliferation. It is notably important for pathogen-induced autophagy but is dispensable for non-infectious autophagy conditions. FNBP1L is also involved in coordinating membrane tubulation and the formation of endocytic vesicles during endocytosis, and may bind to phosphatidylinositol 4,5-bisphosphate and phosphatidylserine. While FNBP1L is implicated in cell biology processes relevant to disease (such as neurodegeneration and infection), there are no approved drug interactions or established mechanisms of action for therapeutic targeting as of current knowledge. No recognized clinical biomarkers or safety concerns uniquely attributable to FNBP1L are documented in the reviewed sources. While not a classical receptor, enzyme, or transporter, FNBP1L is a molecular scaffold/adaptor protein important in cell signaling and cytoskeletal dynamics.

Other names

TOCA1C1orf39Toca-1FLJ20275Transducer of Cdc42-dependent actin assembly protein 1transducer of Cdc42-dependent actin assembly 1FBP1L