Formin homology 2 domain containing protein 3 (FHOD3)

Formin homology 2 domain containing protein 3 (FHOD3) is a member of the diaphanous-related formin protein family that plays a critical role in regulating the actin cytoskeleton, especially in cardiac and skeletal muscle tissue[1][4]. FHOD3 contains multiple regulatory domains, including formin homology (FH1 and FH2) and diaphanous domains, enabling it to nucleate and elongate actin filaments, bundle and cap them, and maintain the structural integrity of myofibrils[2][4][6]. Imbalances in FHOD3 expression or posttranslational regulation are associated with hypertrophic and dilated cardiomyopathies and defects in embryonic cardiogenesis[1][4][6]. The protein’s precise activity and targeting in cardiac cells depend on tissue-specific isoforms and phosphorylation, which modulate its interaction with other proteins and intracellular localization[4]. FHOD3 has not been widely identified as a direct drug target, nor are there currently approved drugs known to target it specifically; however, its strong linkage to cardiac structure, contractile function, and disease make it a candidate for future therapeutic exploration[1][4][6].

Other names

FH1/FH2 domain-containing protein 3FHOD3FHOS2KIAA1695hFHOS2FLJ22297FLJ22717Formactin-2Formin homolog overexpressed in spleen 2CMH28Formactin2