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Formyl Peptide Receptor 2 (FPR2)
- Target
- FPR2
- Molecular classification
- G protein-coupled receptor, GPCR, Formyl peptide receptor subfamily, Rhodopsin-like GPCR
01
Overview
Formyl Peptide Receptor 2 (FPR2), also known as ALX or ALX/FPR2, is a G-protein coupled receptor (GPCR) that plays a significant role in immune regulation and inflammation. It binds a broad range of ligands, including bacterial formyl peptides, mitochondrial peptides, lipid mediators like lipoxin A4, and certain proteins/peptides. FPR2/ALX can mediate both pro-inflammatory and anti-inflammatory/pro-resolving effects depending on the ligand. It is expressed on various cell types, including myeloid cells, lymphoid cells, and non-myeloid tissues. Due to its central role in regulating inflammation, FPR2/ALX represents an attractive drug target for novel therapies aimed at modulating chronic inflammatory states or promoting tissue repair/wound healing.
- Other names
- ALXALX/FPR2
02
Mechanism of action
Agonist or antagonist binding to FPR2/ALX modulates downstream signaling pathways, including MAPK/p38, influencing inflammation and resolution.
03
Biological functions
Immune regulationInflammationChemotaxisCell proliferationCell differentiationApoptosisSuperoxide generationHost defenseModulation of vascularizationSignal transduction
04
Disease associations
InflammationAlzheimer’s diseaseRheumatoid arthritisSystemic amyloidosisNeurodegenerative disease
05
Safety considerations
Dual role in inflammation (pro-inflammatory vs. anti-inflammatory)Potential for ligand-biased signaling leading to different functional outcomesDimerization state influencing functional outcome
06
Interacting drugs
Lipoxin A4 (LXA4)
2 more in the full profile.
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