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Target intelligence / Profile preview
Formyl peptide receptor 3 (FPR3)
- Target
- FPR3
- Molecular classification
- G protein-coupled receptor (GPCR), Class A GPCR
01
Overview
Formyl peptide receptor 3 (FPR3) is a G protein-coupled receptor (GPCR) involved in immune cell chemotaxis and inflammation. It functions as a low-affinity decoy receptor, primarily modulating immune signaling pathways by internalizing ligands and reducing their availability for other formyl peptide receptors. While its precise physiological role remains unclear, research suggests involvement in cellular metabolism and T cell migration during immune responses. It is characterized by rapid phosphorylation and internalization upon ligand binding, distinguishing it from other family members.
- Other names
- FMLPYFPRH2FPRL2
02
Mechanism of action
GPCR signaling modulation, primarily via internalization and decoy receptor function.
03
Biological functions
ImmunomodulationChemotaxis regulationSignal transduction
04
Disease associations
CancerInflammationInfection
05
Safety considerations
Potential for off-target effects due to GPCR family similarity.Complex role in pro-inflammatory and anti-inflammatory processes requires careful consideration in therapeutic targeting.
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