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Target intelligence / Profile preview
Formyl Peptide Receptor Type 2 (FPR2/ALX)
- Target
- FPR2/ALX
- Molecular classification
- G protein-coupled receptor, GPCR, Formyl peptide receptor subfamily
01
Overview
Formyl Peptide Receptor Type 2 (FPR2/ALX) is a G protein-coupled receptor involved in immune regulation. It plays a key role in inflammation resolution through its interaction with specialized pro-resolving mediators like lipoxin A4 and resolvins. It also participates in host defense by recognizing pathogen-associated molecular patterns and promoting chemotaxis and phagocytosis. Due to its dual roles, FPR2 represents an attractive therapeutic target for chronic inflammatory diseases and sepsis.
- Other names
- N-formyl peptide receptor 2ALXALXRALX/FPR2LXA4 Receptor
02
Mechanism of action
Agonism or antagonism of FPR2/ALX receptor to modulate inflammation resolution and immune cell chemotaxis.
03
Biological functions
Inflammation resolutionChemotaxisHost defenseImmune regulationPhagocytosisModulates apoptosisModulates proliferationModulates differentiationIntracellular communicationSoluble mediator generation
04
Disease associations
InflammationSepsisChronic inflammatory diseasesDysregulated immune responsesBacteremia
05
Safety considerations
Depending on ligand context, FPR2 can mediate both pro-inflammatory and anti-inflammatory responses, requiring careful consideration in drug development.Potential for off-target effects due to broad ligand specificity.
06
Interacting drugs
Lipoxin A4 (LXA4)
4 more in the full profile.
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