Formyltransferases involved in purine biosynthesis (N/A)

Formyltransferases are key enzymes in the *de novo* purine biosynthetic pathway, responsible for transferring formyl groups during the multi-step synthesis of purine nucleotides. These enzymes utilize tetrahydrofolate derivatives as one-carbon donors and are essential for building the purine ring structure that ultimately forms inosine monophosphate (IMP), a precursor to both adenine and guanine nucleotides. In humans, both GAR and AICAR transformylase activities reside within a bifunctional enzyme called ATIC. Inhibition of these enzymes disrupts nucleotide balance and impairs DNA/RNA synthesis, making them therapeutic targets, particularly in cancer.

Other names

GAR TransformylaseAICAR TransformylaseAminoimidazole Carboxamide Ribonucleotide TransformylaseATIC

Inhibition of formyl transfer, leading to disruption of purine nucleotide synthesis