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Target intelligence / Profile preview
Forty-two-three domain-containing protein 1 (FYTTD1)
- Target
- FYTTD1
- Molecular classification
- Other (mRNA export adaptor protein, protein-binding)
01
Overview
Forty-two-three domain-containing protein 1 (FYTTD1, also known as UAP56-interacting factor or UIF) is a nuclear adaptor protein essential for the export of mRNA from the nucleus to the cytoplasm[1][2][8]. FYTTD1 functions by utilizing the DDX39B/UAP56-NFX1 (TAP) pathway, ensuring efficient translocation of mRNA to nuclear pores[1][2][8]. It binds to both spliced and unspliced mRNAs and interacts with SSRP1, ALYREF/THOC4, and components of the mRNA export machinery. FYTTD1 is implicated in inherited disorders such as congenital myasthenic syndromes and retinitis pigmentosa[2]. There is currently no evidence that FYTTD1 is a common therapeutic target (e.g., receptor, enzyme, transporter) nor that drugs directly interact with it.
- Other names
- UAP56-interacting factorUIFProtein 40-2-3DKFZp761B1514Putative 40-2-3forty-two-three domain containing 1
02
Biological functions
mRNA bindingmRNA export from nucleusadapter activity in RNA exportassociates with spliced and unspliced mRNAs
03
Disease associations
Myasthenic syndrome (congenital, 3A, slow-channel)Retinitis pigmentosa 13
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