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Four-jointed box protein 1 (FJX1)
- Target
- FJX1
- Molecular classification
- Other (transmembrane glycoprotein; not classified as a classical receptor, ion channel, transporter, enzyme, or transcription factor)[2][6]
01
Overview
Four-jointed box protein 1 is a type II transmembrane glycoprotein encoded by the FJX1 gene in humans. It is orthologous to the Drosophila four-jointed gene, which is involved in growth and patterning during development, particularly in limbs and eyes. In mammals, its function is less well defined; in mice, it acts as an inhibitor of dendrite extension and branching, and may influence the development of neural and other tissues, but its precise role in human biology and pathology remains unclear[1][6][7][2]. There are no known approved drugs, clinical biomarkers, or established links to major disease areas for this protein at present.
- Other names
- four jointed box 1four-jointed box kinase 1FJX1
02
Biological functions
Inhibition of dendrite extension and branchinggrowth and differentiation (developmental processes in model organisms)[6][7][1]
03
Disease associations
Other (no clear associations with cancer, inflammation, cardiovascular or neurodegenerative diseases currently reported)
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