FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR)

FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) is a long non-coding RNA transcribed bidirectionally from the same locus as FOXF1 and regulates gene expression through epigenetic mechanisms, including direct recruitment of chromatin-modifying complexes such as Polycomb Repressive Complex 2 (PRC2) and TrxG/MLL, and by acting as a competing endogenous RNA to sponge microRNAs and proteins that control mRNA stability. FENDRR is essential for normal organ development (heart, lungs, gastrointestinal tract) in mice and is implicated in various human diseases, including cancer (where it can act as either a tumor suppressor or an oncogene depending on cell context), fibrosis, and inflammatory conditions. Notably, altered expression of FENDRR is linked to chemotherapy resistance via modulation of drug transporter genes and transcription factors such as FOXC2, making it a candidate biomarker for prognosis and drug resistance, but not a direct druggable target.

Other names

lincFOXF1onco-lncRNA-21FOXF1-AS1FOXF1AS1TCONS_00024240FOXF1 antisense RNA 1 (head to head)FOXF1 antisense RNA 1 (non-protein coding)FENDRR

Not a direct drug target; for role in drug resistance: regulation of expression of drug efflux transporters (e.g., ABCC10), modulation of FOXC2/FOXL1, and influencing epigenetic silencing through chromatin modification complexes (like PRC2).