FoxO-induced long non-coding RNA 1 (FILNC1)

FoxO-induced long non-coding RNA 1 (FILNC1) is a long non-coding RNA (lncRNA), specifically induced by FoxO transcription factors under conditions of energy stress[3]. FILNC1 acts as a tumor suppressor in renal cell carcinoma, where it is normally expressed at high levels in kidney tissue and found to be downregulated in tumors[3]. Functionally, FILNC1 regulates energy metabolism and cell death by sequestering AUF1, an mRNA-binding protein for c-Myc, thereby suppressing c-Myc translation, reducing glucose uptake and lactate production, and promoting apoptosis under metabolic stress[3]. FILNC1 deficiency results in enhanced tumorigenic potential, and its low expression correlates with poorer clinical outcomes in renal cell carcinoma[3]. There are several overlapping transcript isoforms of FILNC1 arising from the same gene locus[3]. Key points: - FILNC1 is classed as a long non-coding RNA rather than a typical therapeutic target such as a receptor or enzyme. - It has no known direct interacting drugs or therapeutic modulators as of current knowledge; its main role is as an endogenous regulator of cancer cell metabolism and apoptosis. - FILNC1 is a potential prognostic biomarker for renal cell carcinoma because its expression level correlates with disease outcome[3]. - There are no major safety concerns reported, as FILNC1 is not a drug target and interventions to modulate its activity have not been developed or clinically trialed. If a direct therapeutic target effect (e.g., as a receptor, enzyme, transporter) is required, FILNC1 would be categorized as "not a target" (is_target: false) because it is a regulatory non-coding RNA, not a classic druggable protein.

Other names

FILNC1FoxO-induced long non-coding RNA 1