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FOXP3+ Regulatory T Cell (None)
- Target
- None
- Molecular classification
- Cell, Lymphocyte, T cell, Regulatory T cell
01
Overview
FOXP3+ regulatory T cells are a specialized subset of T lymphocytes that play a central role in maintaining immune tolerance and homeostasis. They are defined by the expression of the transcription factor FOXP3, which is essential for their development, function, and lineage specification. They suppress the activation and proliferation of other immune cells to prevent autoimmunity and excessive inflammation.
- Other names
- Regulatory T cellTregFOXP3+ T cell
02
Mechanism of action
Cytokine secretion (IL‑10/TGF‑β), direct suppression
03
Biological functions
Immune suppressionTolerance maintenanceRegulation of immune responsePrevention of autoimmunityControl of inflammation
04
Disease associations
Autoimmune diseasesGraft-versus-host diseaseAllergiesChronic inflammatory disordersCancerIPEX syndrome
05
Safety considerations
Potential for plasticity and conversion to pro-inflammatory phenotypesRisk of dampening beneficial immune responses (e.g., in cancer immunotherapy)
06
Biomarkers
FOXP3 expressionCD4 expressionCD25 expression
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