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Target intelligence / Profile preview
Fractalkine (CX3CL1)
- Target
- CX3CL1
- Molecular classification
- Chemokine, CX3C chemokine
01
Overview
Fractalkine, also known as CX3CL1, is a unique chemokine that exists in both membrane-bound and soluble forms. It functions as an adhesion molecule and chemoattractant, respectively. Its signaling through CX3CR1 orchestrates key aspects of immune cell trafficking under normal physiology as well as diverse pathological states including neurodegeneration, cardiovascular disease, autoimmunity—and potentially cancer progression through effects on angiogenesis.
- Other names
- CX3C ligand 1FKN
02
Biological functions
ChemoattractionCell adhesionCell survivalImmune cell migrationAngiogenesis regulation
03
Disease associations
AtherosclerosisGlomerulonephritisCardiac allograft rejectionRheumatoid arthritisCancerNeurodegenerationCardiovascular diseaseAutoimmunityHIV
04
Safety considerations
Dysregulation linked with multiple diseasesPotential for off-target effects due to broad expression of CX3CR1
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