Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Frameshift Peptide Neoantigen
- Molecular classification
- Peptide antigen, Neoantigen
01
Overview
Frameshift peptide neoantigens are tumor-specific antigens generated by frameshift mutations (insertions or deletions) in coding microsatellites within cancer cells. These mutations disrupt the normal reading frame, producing unique peptide sequences not found in healthy tissues. Due to their foreign nature, they are highly immunogenic and can serve as targets for cancer immunotherapy, particularly in MSI-high tumors.
- Other names
- FSP neoantigenFrameshift-derived neoantigenIndel-derived neoantigen
02
Mechanism of action
Vaccines stimulate T cells to recognize and kill tumor cells expressing the frameshift peptide neoantigen. Immune checkpoint inhibitors can enhance the T cell response.
03
Biological functions
Antigen presentationT cell activationImmune responseTumor rejection (potential)
04
Disease associations
CancerMicrosatellite instability (MSI)-high cancersLynch syndrome-associated cancers
05
Safety considerations
Off-target effects (potential, but unlikely due to tumor specificity)Autoimmunity (potential, but considered low risk)Cytokine release syndrome (potential, but generally mild in clinical trials)
06
Interacting drugs
Vaccines (FSP-based)
1 more in the full profile.
07
Biomarkers
MSI statusMMR deficiencyPresence of specific frameshift mutations (e.g., AIM2, HT001, TAF1B)HLA type (for peptide binding prediction)T cell response to FSP
Beyond the preview
Go deeper on Frameshift Peptide Neoantigen.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Frameshift Peptide Neoantigen.