Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
FRAS1-related extracellular matrix protein 3 (FREM3)
- Target
- FREM3
- Molecular classification
- Other (Extracellular matrix protein)
01
Overview
FRAS1-related extracellular matrix protein 3 (FREM3) is an extracellular matrix protein encoded by the FREM3 gene and is a member of the FRAS1/FREM protein family[1][4]. FREM3 is highly expressed in the brain, where it likely contributes to cell–cell interactions and helps maintain the structural and functional integrity of nervous tissue[1][2]. Reduced expression of FREM3, associated with certain genetic variants, has been linked to increased risk of a depression subtype characterized by blunted amygdala activity and slower cognitive processing, as well as decreased expression with aging[1][2]. While FREM3 shares homology with other FRAS1/FREM family members implicated in congenital disorders such as Fraser syndrome, currently there is no evidence directly linking FREM3 mutations to these syndromes[1][2].
- Other names
- FRAS1 related extracellular matrix 3FREM3FRAS1-related extracellular matrix protein 3
02
Biological functions
Cell–cell interactionCell adhesionMaintenance of structural and functional integrity in nervous tissueNeural development and function[1][2][4]
03
Disease associations
Depression (risk factor/association with subtypes)Brain aging (expression decreases with age)[1][2]
04
Biomarkers
FREM3 genetic variants (e.g., rs7676614, rs1391187) as risk markers for subtypes of depression characterized by blunted amygdala reactivity and slower processing speed[1][2]
Beyond the preview
Go deeper on FRAS1-related extracellular matrix protein 3 (FREM3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on FRAS1-related extracellular matrix protein 3 (FREM3).