Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Free Fatty Acid Receptor 1 (FFAR1)
- Target
- FFAR1
- Molecular classification
- G-protein-coupled receptor, GPCR, Rhodopsin-like Class A GPCR
01
Overview
Free Fatty Acid Receptor 1 (FFAR1) is a G-protein-coupled receptor that acts as a metabolic sensor for circulating free fatty acids. It is highly expressed in pancreatic β-cells, where it modulates insulin secretion in response to elevated glucose levels. Activation of FFAR1 enhances glucose-stimulated insulin secretion and stimulates incretin hormone release. Central pharmacological activation may offer therapeutic potential against obesity by increasing energy expenditure and reducing inflammation/stress responses within the hypothalamus. Synthetic agonists like TAK-875 have been developed for diabetes treatment but faced challenges related to safety profiles during clinical development.
- Other names
- FFA1RGPR40GPCR40
02
Mechanism of action
Agonist of FFAR1, enhances glucose-stimulated insulin secretion from pancreatic β-cells
03
Biological functions
Metabolic sensorRegulation of insulin secretionRegulation of incretin hormone releaseRegulation of appetiteRegulation of body weightRegulation of energy expenditureSignal transduction
04
Disease associations
Type 2 diabetesObesity
05
Safety considerations
Safety profile during clinical development (e.g., with TAK-875)
06
Interacting drugs
TAK-875
Beyond the preview
Go deeper on Free Fatty Acid Receptor 1 (FFAR1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Free Fatty Acid Receptor 1 (FFAR1).