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Target intelligence / Profile preview
Free fatty acid receptor 2 (FFAR2)
- Target
- FFAR2
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like GPCR
01
Overview
Free Fatty Acid Receptor 2 (FFAR2), also known as GPR43, is a G-protein coupled receptor primarily activated by short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate. It plays a key role in glucose/insulin regulation, immune modulation, and lipid metabolism. FFAR2 is considered a therapeutic target for metabolic disorders such as diabetes and obesity.
- Other names
- GPR43
02
Mechanism of action
Agonists/antagonists modulate receptor activity, influencing downstream signaling pathways involved in glucose homeostasis, immune response, and lipid metabolism.
03
Biological functions
Signal transductionGlucose regulationInsulin secretionImmune regulationLipid metabolismGLP-1 modulation
04
Disease associations
Diabetes mellitusObesityInflammatory diseasesNon-alcoholic fatty liver disease (NAFLD)Metabolic syndromeCertain cancersNeurological diseasesInfectionsKetoacidosis
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