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Target intelligence / Profile preview
Free Fatty Acid Receptor 3 (FFAR3)
- Target
- FFAR3
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Receptor
01
Overview
Free Fatty Acid Receptor 3 (FFAR3), also known as GPR41, is a G protein-coupled receptor (GPCR) that senses short-chain fatty acids (SCFAs) produced by gut microbiota. Activation of FFAR3 primarily couples to Gi proteins, leading to inhibition of adenylate cyclase and reduced cAMP levels. It plays a role in regulating insulin secretion from pancreatic beta cells, energy homeostasis, and glucose metabolism, making it a potential therapeutic target for metabolic diseases.
- Other names
- GPR41
02
Mechanism of action
Gi/o protein-mediated inhibition of cAMP production upon binding of short-chain fatty acids, leading to downstream effects such as inhibition of insulin secretion.
03
Biological functions
Signal transductionNutrient sensingRegulation of insulin secretionModulation of cAMP levelsEnergy homeostasis regulationGlucose metabolism regulation
04
Disease associations
Metabolic diseaseType 2 diabetesObesity
05
Safety considerations
Potential for off-target effects due to GPCR promiscuity.Limited understanding of long-term consequences of FFAR3 modulation.
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