Friend leukemia integration 1 transcription factor (FLI1)

Friend leukemia integration 1 transcription factor (FLI1) is a proto-oncogene and a member of the ETS family of transcription factors encoded by the FLI1 gene. It regulates transcription of many genes involved in cell proliferation, differentiation, and survival, with a primary role in hematopoietic and endothelial cell development[1][3][4]. FLI1 is critical for maintaining and differentiating hematopoietic stem cells, controlling vasculogenesis and angiogenesis, and regulating blood cell and platelet formation. Aberrant expression or chromosomal translocation involving FLI1, especially the EWS-FLI1 fusion, is a major driver of Ewing sarcoma and is implicated in leukemias, autoimmune diseases, and platelet dysfunction disorders. FLI1 is considered a promising therapeutic target in oncology and autoimmunity, though challenges remain due to the difficulty in developing specific transcription factor inhibitors[3][1][4][2][5][6].

Other names

Fli-1 proto-oncogeneTranscription factor ERGBEWSR2SIC-1Proto-oncogene Fli-1Ewing sarcoma breakpoint region 2Friend leukemia virus integration 1BDPLT21

Inhibition of DNA-binding or RNA-binding activity of EWS-FLI1 fusion protein to suppress abnormal gene transcription and proliferation (in preclinical and experimental drug candidates); Small molecules that interfere with transcriptional activation function