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Target intelligence / Profile preview
Frizzled-10 Receptor (FZD10)
- Target
- FZD10
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Frizzled-10 (FZD10) is a member of the frizzled gene family encoding 7-transmembrane domain proteins that function as receptors for Wnt signaling proteins. FZD10 plays a pivotal role in the canonical Wnt/β-catenin signaling pathway and regulates diverse biological processes including cell proliferation, cell polarity, embryonic development, and neural differentiation. It is implicated in tumorigenesis and sensory neuron development disorders, making it a potential therapeutic target.
- Other names
- Frizzled Class Receptor 10Seven Transmembrane Spanning ReceptorFzE7HFz10CD350 Antigen
02
Mechanism of action
Wnt/FZD signaling pathway modulation (antagonists)
03
Biological functions
Signal transductionCell proliferationCell polarityEmbryonic developmentNeural differentiationSensory neuron developmentWnt signaling
04
Disease associations
CancerSensory neuron development disorders
05
Safety considerations
Potential for off-target effects due to Wnt pathway involvement in multiple developmental processes.
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