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Target intelligence / Profile preview
Frizzled class receptor 1 (FZD1)
- Target
- FZD1
- Molecular classification
- G protein-coupled receptor, Receptor, Frizzled family
01
Overview
Frizzled class receptor 1 (FZD1) is a seven-transmembrane G protein-coupled receptor that serves as a key receptor for Wnt ligands. It plays a crucial role in both canonical and non-canonical Wnt signaling pathways, influencing cell proliferation, differentiation, migration, and polarity. FZD1 is implicated in development, neurobiology, and cancer biology, and its dysregulation contributes to diseases such as cancer and schizophrenia, including tumor progression and drug resistance mechanisms.
- Other names
- Frizzled-1Fz-1
02
Mechanism of action
Wnt signaling modulation
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationCell polarityEmbryonic developmentTissue homeostasisNeurogenesisAxon guidanceDendritogenesisSynapse formationSynapse stabilitySynapse plasticity
04
Disease associations
CancerSchizophreniaMultidrug resistance
05
Safety considerations
Potential for broad effects due to involvement in multiple signaling pathwaysOncogenic potential due to role in cell proliferation and survival
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