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Frizzled homolog 10 receptor (FZD10)

Target: FZD10
Molecular classification: G protein-coupled receptor, Receptor, Seven transmembrane receptor

Overview

FZD10 is a member of the frizzled gene family, encoding cell surface receptors for Wnt proteins. It is a G protein-coupled receptor with seven transmembrane domains and plays a crucial role in regulating cell proliferation, differentiation, and migration via the canonical Wnt/beta-catenin signaling pathway. FZD10 is highly expressed in the placenta and fetal kidney and is abundantly expressed in the adult cerebellum. Overexpression is observed in certain cancers. Dysregulation can impact tumor progression.

Other names: Frizzled Class Receptor 10Frizzled Family Receptor 10Seven Transmembrane Spanning ReceptorHFz10FzE7CD350 AntigenCD350

Mechanism of action

Activation of the Wnt/beta-catenin signaling pathway leading to stabilization and nuclear translocation of beta-catenin and subsequent transcriptional activation of target genes.

Biological functions

Signal transductionCell proliferationCell differentiationCell migrationRegulation of gene expression

Disease associations

CancerFallopian tube serous adenocarcinomaColorectal cancer

Safety considerations

Potential for off-target effects due to the widespread role of Wnt signaling in development and tissue homeostasis.Aberrant activation of Wnt signaling can promote tumorigenesis.

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