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Target intelligence / Profile preview
Frizzled class receptor 2 (FZD2)
- Target
- FZD2
- Molecular classification
- Receptor, Atypical GPCR, Frizzled Receptor
01
Overview
FZD2 is a member of the frizzled gene family, encoding atypical G protein-coupled receptors (GPCRs) that act as cell-surface receptors for Wnt signaling proteins. It plays a role in developmental regulation, cell polarity, embryonic development, neural synapse formation, and cell proliferation and migration. FZD2 functions as an oncogene in certain cancers and has been linked to developmental disorders.
- Other names
- Frizzled-2Fz-2Drosophila polarity gene homolog 2frizzled family receptor 2
02
Mechanism of action
Wnt ligand binding induces conformational changes leading to downstream signal transduction via Dishevelled protein activation.
03
Biological functions
Wnt signaling pathwayCell polarityEmbryonic developmentNeural synapse formationCell proliferationCell migrationSignal transduction
04
Disease associations
CancerDevelopmental Disorders
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