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Frizzled class receptor 4 (FZD4)
- Target
- FZD4
- Molecular classification
- Frizzled gene family, G-protein-coupled receptor, GPCR, Seven-transmembrane receptor, Receptor
01
Overview
FZD4 encodes a cell surface receptor, a key component of the Wnt signaling pathway. This pathway regulates crucial cellular processes. FZD4 binds Norrin with high affinity, which is essential for vascular development in the retina and inner ear and specialization of retinal cells during early development. FZD4 primarily activates the canonical Wnt/β-catenin signaling pathway but can also participate in noncanonical pathways. Mutations or variants in the FZD4 gene are linked to Familial Exudative Vitreoretinopathy and dysregulated expression has been observed across different cancer types.
- Other names
- CD344Fz-4
02
Mechanism of action
Wnt signaling pathway modulation
03
Biological functions
Cell divisionCell proliferationCell adhesionCell migrationTissue developmentTissue organizationVascular developmentSignal transductionRetinal cell specializationAngiogenesis
04
Disease associations
Familial Exudative VitreoretinopathyCancer
05
Safety considerations
Dysregulation can lead to tumor pathogenesisMutations cause retinal vascularization defects
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