Frizzled class receptor 6 (FZD6)

Frizzled class receptor 6 (FZD6) is a member of the frizzled family of G protein-coupled receptors embedded in the cell membrane, primarily serving as a receptor for Wnt proteins[1][3][6]. FZD6 plays a crucial role in both canonical (β-catenin dependent) and non-canonical (planar cell polarity, PCP) Wnt signaling pathways, regulating vital processes such as cell proliferation, adhesion, migration, embryonic tissue patterning, and organ morphogenesis[1][2][3][4]. Its physiological significance is most evident in nail and hair development; mutations in FZD6 cause isolated autosomal recessive nail dysplasia (nonsyndromic congenital nail disorder 10)[1]. FZD6 is also implicated in various cancers, and its expression is associated with inflammatory and neoplastic conditions of the intestine and other organs[4][5]. Structurally, FZD6 has seven transmembrane domains, a N-terminal cysteine-rich domain that binds Wnt ligands, and lacks the PDZ-binding motif present in some other family members[3][2]. There are currently no approved drugs that target FZD6 directly, but the receptor is considered a promising target for modulation of Wnt signaling in several disease states[2][3].

Other names

Frizzled-6FZD6Fz-6hFz6Hfz6FZ-6FZ6HFZ6NDNC1NDNC10frizzled-6frizzled 6seven transmembrane spanning receptorfrizzled family receptor 6frizzled homolog 6seven transmembrane helix receptor

Drugs or tool compounds targeting FZD6 would act by modulating Wnt signaling pathways, either by antagonizing or potentiating receptor-ligand interactions, thereby affecting downstream signaling such as β-catenin dependent (canonical) or planar cell polarity (non-canonical) pathways[3][2].