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Frizzled class receptor 7
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Frizzled class receptor 7 (FZD7) is a member of the frizzled gene family, encoding a seven-transmembrane domain receptor primarily functioning as a cell surface receptor for Wnt signaling proteins. It plays crucial roles in embryonic development, cell polarity, neural synapse formation, stem cell maintenance, and is frequently upregulated in several cancers including colorectal cancer, hepatocellular carcinoma, and triple-negative breast cancer. Upon ligand binding, it activates the canonical Wnt/β-catenin pathway and non-canonical pathways like PCP and Wnt/calcium, impacting cell proliferation, differentiation, and cytoskeletal organization.
- Other names
- FzE3Frizzled family receptor 7Fz7
02
Mechanism of action
Wnt signaling modulation
03
Biological functions
Signal transductionDevelopmental patterningStemness maintenanceCell polarity establishmentNeural synapse formationCell proliferationCell differentiation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to Wnt pathway involvement in multiple tissues and processes
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