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Target intelligence / Profile preview
Frizzled Class Receptor 8 (FZD8)
- Target
- FZD8
- Molecular classification
- G protein-coupled receptor, Seven-transmembrane receptor, Receptor
01
Overview
Frizzled-8 (FZD8) is a seven-transmembrane domain receptor belonging to the frizzled gene family. It functions as a receptor for Wnt signaling proteins, primarily involved in the canonical Wnt/β-catenin pathway but also participating in non-canonical pathways like Planar Cell Polarity (PCP) and Wnt/Ca²⁺ signaling. Upon ligand binding, it forms complexes with co-receptors such as LRP5 or LRP6, triggering downstream transcriptional activity important for development, tissue maintenance, cell fate determination, cell polarity, tissue patterning, and proliferation. FZD8 is implicated in diseases such as renal cell carcinoma, cystitis, and Axenfeld-Rieger Syndrome type I.
02
Mechanism of action
WNT pathway modulation
03
Biological functions
Signal transductionDevelopmental processesCell fate determinationCell polarityTissue patterningCell proliferationWnt signaling
04
Disease associations
Renal cell carcinomaCystitisAxenfeld-Rieger Syndrome type ICancer
05
Safety considerations
Potential for off-target effects due to Wnt pathway involvement in various tissues
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